Triazole, oxadiazole and thiadiazole derivative as ppar...

Details Triazole, oxadiazole and thiadiazole derivative as ppar... Triazole, oxadiazole and thiadiazole derivative as ppar...

A - Human Necessities

61

K

A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 3/10 (2006.01) C07D 249/08 (2006.01) C07D 271/10 (2006.01) C07D 285/12 (2006.01)

Patent

CA 2549385

The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.

La présente invention a trait à des composés de formule structurelle (I), dans laquelle : (a) X est choisi parmi le groupe constitué d'une liaison simple, O, S, S(O)¿2? et N ; (b) U est une liaison aliphatique ; (c) Y est choisi parmi le groupe constitué de O, C, S, NH et une liaison simple ; (d) W est N, O ou S ; (e) E est C(R3)(R4)A ou A et dans laquelle (f) A est choisi parmi le groupe constitué de carboxyle, tétrazole, alkylnitrile en C¿1? C¿6?, carboxamide, sulfonamide et acylsulfonamide. Les autres substituants sont tels que définis dans les revendications ; les composés sont des modulateurs des récepteurs activés de la prolifération des peroxisomes (PPAR) et sont utiles pour le traitement du diabète et d'autres troubles métaboliques.

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