Triazoles and their use as bradykinin b1 receptor antagonists

Details Triazoles and their use as bradykinin b1 receptor antagonists Triazoles and their use as bradykinin b1 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/4192 (2006.01) A61K 31/497 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2583158

Compounds of Formula (I): are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention concerne des composés de la formule (I), dans laquelle t représente 0, 1 ou 2; X est choisi parmi NH-, -S-, -O-, -NRc-, ou NRg-. A représente un groupe de la formule (a) ou (b). Ces composés sont efficaces au niveau du traitement de la douleur et de maladies, par exemple celles médiées par une inflammation. L'invention concerne également de nouveaux composés, des analogues, des promédicaments et des dérivés de ceux-ci pharmaceutiquement acceptables, des compositions pharmaceutiques et des procédés de prophylaxie et de traitement de maladies et autres états impliquant une douleur, une inflammation, et analogue. Elle concerne enfin des processus de fabrication de tels composés ainsi que des intermédiaires utilisés dans ces processus.

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