Triazolo derivatives and process for their preparation

Details Triazolo derivatives and process for their preparation Triazolo derivatives and process for their preparation

C - Chemistry, Metallurgy

07

D

167/208, 260/238

C07D 413/04 (2006.01) A61K 31/395 (2006.01) C07D 249/14 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 487/04 (2006.01) C07D 487/10 (2006.01)

Patent

CA 2028610

NOVEL TRIAZOLO DERIVATIVES AND PROCESS FOR THEIR PREPARATION A b s t r a c t This invention relates to novel triazolo deriva- tives, a process for the preparation thereof, pharmaceuti- cal compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatment of the said diseases. The new triazolo derivatives of the general for- mulae (Ia) and (Ib), Image (Ia) (Ib) 23305-1175 wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C1-4 alkyl substituent(s); or a group of the formula SR1, wherein R1 stands for straight or branched chained C1-4 alkyl or phenyl-(C1-4 alkyl); or a group of the formula NR2R3, wherein R2 and R3 each represent hydrogen, straight or branched chained C1-12 alkyl, C2-6 alkenyl or phenyl-(C1-4 alkyl); R4 and R7 each represent hydrogen, C1-6 alkyl or phenyl- (C1-4 alkyl) optionally bearing one or more halogen substituent(s); R5 and R6 each stand for C1-4 alkyl optionally substituted by a C1-4 alkoxycarbonyl group; a heterocyclic group or a phenyl group optionally bearing one or more halogen, hydroxyl, cyano, nitro, alkyl, methylene dioxy, carbamoylmethoxy, di-(C1-4 alkyl)- amino or C1-4 alkoxy substituent(s) which latter may carry a di-(C1-4 alkyl)-amino group; furthermore one of R5 and R6 may represent hydrogen, or R5 and R6 together stand for C4-15 alkylene, or together with the adjacent carbon atom they are attached to form a heterocyclic group bearing a phenyl-(C1-4 alkyl) substituent, posses valuable antianginal and tranquillant/sedative properties and are useful in therapy.

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