A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5025 (2006.01) C07D 237/32 (2006.01) C07D 237/34 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2542536
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson~s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to .alpha.2.delta.-1 subunit of Ca channels.
La présente invention concerne une méthode d'utilisation de composés de triazolo-pyridazine dans le traitement de la douleur neuropathique. La présente invention concerne également l'utilisation de composés de triazolo-pyridazine dans le traitement de troubles psychiatriques et de l'humeur tels que, par exemple, la schizophrénie, l'anxiété, la dépression, les troubles bipolaires, et les attaques de panique, ainsi que dans le traitement de la douleur, de la maladie de Parkinson, du dysfonctionnement cognitif, de l'épilepsie, des troubles du rythme circadien et du sommeil tels que les troubles du sommeil induits par des semaines de travail à horaire irrégulier et le décalage horaire, la toxicomanie, la surconsommation de médicaments, le sevrage et d'autres maladies. La présente invention concerne également de nouveaux composés de triazolo-pyridazine qui fixent sélectivement la sous-unité .alpha.¿2?.delta.-1 des canaux Ca.
Gunzner Janet
Lebsack Alec D.
Munoz Benito
Pracitto Richard
Venkatraman Shankar
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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