Triazolopyridines as anti-inflammatory agents

Details Triazolopyridines as anti-inflammatory agents Triazolopyridines as anti-inflammatory agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2440222

The present invention relates to novel triazolo-pyridines of the formula I wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen; R2 is selected from the group consisting of hydrogen, (C1-C6) alkyl or other suitable substituents; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; s is an integer from 0-5; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

L'invention porte: sur de nouvelles triazolo-pyridines de formule (I) dans laquelle: Het est un est hétérocycle facultativement substitué à 5 éléments contenant un ou deux hétéroatomes sélectionnés parmi N, S et O, et dont l'un d'eux au moins doit être N; R?2¿ est sélectionné parmi H, (C¿1?-C¿6?) alkyle ou d'autres substituants acceptables; R?3¿ est sélectionné parmi H, (C¿1?-C¿6?) alkyle ou d'autres substituants acceptables; s est un entier de 0 à 5; sur des intermédiaires servant à leur préparation, sur des préparations pharmaceutiques les contenant et sur leurs utilisations médicales. Lesdits composés, de puissants inhibiteurs des MAP kinases et de préférence de la p38 kinase, peuvent servir au traitement des inflammations, de l'ostéoarthrite, de l'arthrite rhumatoïde, du cancer, de la reperfusion ou de l'ischémie lors d'attaques ou de crises cardiaques, des maladies auto-immunes et d'autres troubles.

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