Triazolopyridinylsulfanyl derivatives as p38 map kinase...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2576297

A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; Forumla (I) and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.

L'invention concerne un composé de formule (I), ou un sel pharmaceutiquement acceptable et/ou un solvate pharmaceutiquement acceptable (y compris un hydrate) de celui-ci (I). La présente invention porte également sur l'utilisation d'un composé de formule (I) pour traiter une maladie, un trouble ou un état dû au TNF, ou bien une maladie, un trouble ou un état dû au p38, notamment les maladies des voies respiratoires d'origine allergique ou non, plus particulièrement les maladies des voies respiratoires obstructives ou inflammatoires, et en particulier la maladie pulmonaire obstructive chronique.

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