Triazolopyrimidine derivatives as glycogen synthase kinase 3...

Details Triazolopyrimidine derivatives as glycogen synthase kinase 3... Triazolopyrimidine derivatives as glycogen synthase kinase 3...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2592457

This invention concerns a compound of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents phenyl, pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; C1-6alkyl substituted with formyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl or C1- 6alkylcarbonyloxy; X represents a direct bond; -(CH2)n3- or -(CH2)n4-X1a-X1b-; R2 represents an optionally substituted cyclic system; provided that N,3- diphenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine is not included ; their use, pharmaceutical compositions comprising them and processes for their preparation.

L'invention concerne un composé de formule (I), un N-oxyde, un sel d'addition pharmaceutique acceptable, un amine quaternaire et sa forme isomérique stéréochimiquement isomère, où l'anneau A représente phényle, pyridyle, pyrimidinyle, pyridazinyle ou pyrazinyle; R1 représente hydrogène; aryle; formyle; C1-6 alkylcarbonyle; C1-6 alkyle; C1-6alkyloxycarbonyle; C1-6ealkyle substitué par formyle, C1-6 alkylcarbonyle, C1-6 alkyloxycarbonyle ou C1-6 alkylcarbonyloxy; X représente une liaison directe; -(CH2)n3- ou -(CH2)n4-X1a-X1b-; R2 représente un système cyclique éventuellement substitué à condition que N,3-diphényl-3H-1,2,3-triazolo[4,5-d]pyrimidine-5-amine ne soit pas inclus; leur utilisation, les compositions pharmaceutiques les contenant et les procédés pour leur préparation.

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