C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 167/236
C07D 413/04 (2006.01) A61K 31/395 (2006.01) C07D 249/14 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2028557
NOVEL TRIAZOLYL HYDRAZIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION A b s t r a c t This invention relates to novel triazolyl hydrazide derivatives and a process for the preparation thereof. The new triazolyl hydrazide derivatives of the general formula (I), Image (I) wherein Q represents hydrogen or a heterocyclic group optionally substituted by a C1-4 alkyl group; or a group of the formula SR1, wherein R1 stands for C1-4 alkyl or phenyl-(C1-4 alkyl), or a group of the formula NR2R3, wherein R2 and R3 each represent hydrogen, straight or branched chained C1-6 alkyl or C2-6 alkenyl; Z represents hydrogen or a group of the formula (C=X)-(N-R4)-NR5R6, wherein X stands for oxygen or sulfur, R4, R5 and R6 each stand for hydrogen or C1-4 alkyl; R7 denotes hydrogen, C1-4 alkyl or phenyl-(C1-4 alkyl) optionally substituted by one or more halogen atom(s), R8 stands for hydrogen or a group of the formula -(C=X)-(N-R4)-NR5R6, wherein X, R4, R5 and R6 are as stated above, with the proviso that if Z represents a group of the formula -(C=X)-(N-R4)-NR5R6, R8 stands for hydrogen, and if Z represents hydrogen, R8 stands for a group of the formula (C=X)-(N-R4)-NR5R6, and pharmaceutically acceptable acid addition salts thereof exert valuable antianginal and/or gastric ulcer inhibiting properties and are useful in therapy.
Barkoczy Jozsef
Fekete Marton
Gacsalyi Istvan
Gorgenyi Frigyes
Gyertyan Istvan
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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