C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/41 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2657776
Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.
L'invention concerne des composés susceptibles d'agir comme de puissants antagonistes du récepteur CCR2 ou CCR9. Des essais sur des animaux démontrent l'utililté de ces composés pour le traitement d'inflammations, une maladie caractéristique pour CCR2 et CCR9. Ces composés sont généralement des dérivés d'arylsulfonamide que l'on utilise dans des compositions pharmaceutiques, des procédés de traitement de maladies médiées par CCR2, CCR9, comme témoins dans des dosages pour l'identification d'antagonistes de CCR2 et pour l'identification d'antagonistes de CCR9.
Charvat Trevor T.
Hu Cheng
Melikian Anita
Novack Aaron
Pennell Andrew M.k.
Cassan Maclean
Chemocentryx Inc.
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