C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 9/10 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2657670
A compound of the formula (I) for treating a CCR2-mediated condition or disease or a CCR9-mediated condition or disease, where the disease or condition is selected from the group consisting of atherosclerosis, restenosis, multiple sclerosis, inflammatory bowel disease, renal fibrosis, rheumatoid arthritis, obesity, diabetes, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, idiopathic pneumonia syndrome, pulmonary fibrosis, transplantation rejection, graft- versus- host disease, cancer, and neuropathic pain wherein Ar is selected from the group consisting of substituted or unsubsituted C.beta.-io aryl and substituted or unsubstituted 5- to 10- membered heteroaryl; Y1 to Y4 are selected from the group consisting of -CR3a- to -CR3d-, -N-, and -N+(O)-, wherein at least one of Y1, Y2, Y3, or Y4 is -N-.
L'invention concerne des composés agissant comme antagonistes puissants du récepteur CCR2 ou CCR9. Une expérimentation sur des animaux démontre que ces composés sont utiles dans le traitement de l'inflammation, une maladie caractéristique pour CCR2 et CCR9. D'une manière générale, les composés sont des dérivés d'aryl sulfonamide et sont utiles dans des compositions pharmaceutiques, des procédés pour le traitement de maladies à médiation par CCR2, de maladies à médiation par CCR9, comme témoins dans des dosages permettant l'identification d'antagonistes de CCR2 et d'antagonistes de CCR9.
Charvat Trevor T.
Hu Cheng
Jin Jeff
Li Yandong
Melikian Anita
Cassan Maclean
Chemocentryx Inc.
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