A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 29/16 (2006.01) A01N 59/16 (2006.01) A61L 2/18 (2006.01) A61L 15/44 (2006.01) A61L 17/00 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2366380
The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.
La présente invention concerne des articles médicaux polymères contenant des combinaisons de composés à base de triclosan et d'argent. L'invention est fondée, au moins en partie, sur la découverte du fait que ces agents agissent de manière synergique, ce qui permet de les utiliser dans des quantités relativement faibles. On a découvert antérieurement que le triclosan peut être particulièrement utile lorsqu'il est utilisé conjointement avec la chlorhexidine. Dans cette invention, on a cependant découvert que l'on peut fabriquer des articles médicaux ayant des propriétés antimicrobiennes qui contiennent du triclosan mais sont exempts de chlorhexidine. Ces articles médicaux présentent l'avantage de prévenir ou d'inhiber une infection tout en évitant les réactions adverses indésirables à la chlorhexidine chez les individus qui pourraient être sensibles à cette substance.
Modak Shanta
Sampath Lester
Bereskin & Parr
The Trustees Of Columbia University
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