Tricyclic 1,2,4-triazine oxides and compositions therefrom...

Details Tricyclic 1,2,4-triazine oxides and compositions therefrom... Tricyclic 1,2,4-triazine oxides and compositions therefrom...

C - Chemistry, Metallurgy

07

D

C07D 253/10 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 491/052 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2603088

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

La présente invention se rapporte à des 1-oxydes de 1,2,4-triazine tricycliques innovants et à des 1,4-dioxydes de 1,2,4-triazine tricycliques innovants de formule : (I), ainsi qu'aux analogues apparentés. Elle se rapporte également à leur préparation et à leur utilisation en tant que médicaments sélectifs de l'hypoxie et que radiosensibilisants destinés au traitement du cancer, seuls ou en combinaison avec une radiothérapie et/ou d'autres médicaments anticancéreux.

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