Tricyclic 2,3,4,5-tetrahydro-1h-3-benzazepines, their use...

Details Tricyclic 2,3,4,5-tetrahydro-1h-3-benzazepines, their use... Tricyclic 2,3,4,5-tetrahydro-1h-3-benzazepines, their use...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 223/14 (2006.01) C07D 223/32 (2006.01) C07D 405/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2157668

Tricyclic benzazepines having general formula (I) wherein A together with the .alpha.- and .beta.-marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran, thiophene, oxazole, pyrrole pyrroline, tetrahydropyridine or dioxole ring, R1 is H or alkyl, R2 and R3 independently an H, alkoxy, halogen, nitro, cyano or hydroxy, or R2 and R3 together may form a furan, dihydrofuran, cyclopentene or dioxole ring and R4 is H, alkoxy, nitro, cyano, hydroxy or halogen, or a pharmaceutically acceptable salt thereof, are useful in treatment of certain disorders in the central nervous system, e.g., psychosis, pain, depression, sleep disturbances, dyskinesia, Parkinson's disease, stroke.

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