Tricyclic 2-pyrimidone compounds useful as hiv reverse...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 31/18 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01)

Patent

CA 2473420

The present invention relates to tricyclic 2-pyrimidone compounds of formula (I), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

La présente invention concerne des composés 2-pyrimidones tricycliques représentés par la formule (I), ou des formes stéréoisomériques, des mélanges stéréoisomériques, ou des sels acceptables d'un point de vue pharmaceutique de ceux-ci, utilisés en tant qu'inhibiteurs de la transcriptase inverse du VIH, ainsi que des compositions pharmaceutiques et des kits diagnostiques comprenant lesdits composés, et des méthodes d'utilisation de ceux-ci dans le traitement d'une infection virale ou en tant que standard ou réactif de dosage.

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