Tricyclic amines

Details Tricyclic amines Tricyclic amines

C - Chemistry, Metallurgy

07

D

167/226, 260/277

C07D 221/10 (2006.01) A61K 31/435 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1264749

ABSTRACT Compounds of the formula Image wherein C1 and N4 are in trans configuration to each other, Y is OH, R1COO, R2R3NCOO- or R4O whereby R1 is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-hydroxyphenyl group or a 3- or 4-alkanoyloxyphenyl group with the formula Image wherein R5 is an alkyl group having 1-6 carbon atoms, or R1 is a group Image wherein R6 is hydrogen, an alkyl group having 1 to 5 carbon atoms or a phenyl group, R7 is hydrogen, an alkyl group having 1 to 5 carbon atoms or an acyl group and R8 is hydrogen or an alkyl group having 1 to 5 carbon atoms, R2 is hydrogen, an alkyl group having 1-5 carbon atoms, a phenethyl, benzyl or phenyl group which may be mono- or disubstituted in the aromatic part with a methyl, methoxy, hydroxy, nitro or cyano group or a halogen, R3 is H, an alkyl group having 1 to 5 carbon atoms or a phenyl group or R2 and R3 together with the nitrogen atom form a 5, 6 or 7 membered ring that may contain 1 to 3 double bonds and/or 1 or 2 further hetero- atoms selected from N, O and S, and R4 is an allyl or benzyl group and R is hydrogen or the group Image wherein n is 3 or 4 and R9 is hydrogen, an alkanoyl group having 2-6 carbon atoms or benzoyl, as bases and pharmaceu- tically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.

452852

Affiliated with

Also associated with

Rating

Tricyclic amines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic amines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic amines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1319293