Tricyclic anilide heterocyclic cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 519/00 (2006.01) A61K 31/4745 (2006.01) A61K 31/4985 (2006.01) A61K 31/5517 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2689444

Compounds of formula I: wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des compositions de la formule I: où les variables A1, A2, B, m, n, J, R4, G1, G2, G3 et Y sont telles que décrites ici, qui sont des antagonistes de récepteurs CGRP et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué, comme la migraine. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles le CGRP est impliqué.

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