C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4738 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61P 25/06 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2579850
The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
L'invention concerne des composés représentés par la formule I (dans laquelle A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a,R5b,R5c, R6,m et n sont tels que définis dans la description)utilisés comme antagonistes des récepteurs CGRP et pour traiter et prévenir des maladies dans lesquelles le CGRP est impliqué, telles maux de tête, migraines et céphalées vasculaires de Horton. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés et compositions afin de prévenir ou traiter des maladies dans lesquelles CGRP est impliqué.
Bell Ian M.
Gallicchio Steven N.
Theberge Cory R.
Zartman C. Blair
Zhang Xufang
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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