Tricyclic anilide spirolactam cgrp receptor antagonists

Details Tricyclic anilide spirolactam cgrp receptor antagonists Tricyclic anilide spirolactam cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/4745 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2579717

The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

La présente invention concerne des composés de formule (I) (dans laquelle A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m et n sont tels que définis dans la description) utiles comme antagonistes des récepteurs CGRP et utiles pour traiter ou prévenir des affections dans lesquelles le CGRP joue un rôle, telles que la céphalée, la migraine et l'algie vasculaire de la face. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et de ces compositions pour prévenir ou traiter les affections susmentionnées.

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