Tricyclic benzazepine vasopressin antagonists

Details Tricyclic benzazepine vasopressin antagonists Tricyclic benzazepine vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 471/14 (2006.01) C07D 487/14 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2210631

Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

L'invention porte sur des composés tricycliques de formule générale (I) présentant une activité antogoniste vis-à-vis des récepteurs V1 et/ou V2 et une activité in vivo antagoniste de la vasopressine, sur des procédés d'utilisation de ces composés dans le traitement de maladies caractérisées par un excès de réabsorption rénale d'eau et un procédé de préparation desdits composés.

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