Tricyclic carbamate compounds useful for inhibition of...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/4545 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) C07D 221/16 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2174105

A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of formula (1.0). Also disclosed are novel compounds of formulae (1.1, 1.2 and 1.3). Also disclosed are processes for making 3-substituted compounds of formulae (1.1, 1.2 and 1.3). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formulae (1.1, 1.2 and 1.3).

Un procédé, qui permet d'inhiber la fonction Ras et donc la croissance cellulaire, consiste à administrer un composé de formule (1.0). On décrit aussi de nouveaux composés de formules (1.1, 1.2 et 1.3). On décrit en outre des procédés donnant des composés 3-substitués des formules (1.1, 1.2 et 1.3). On décrit enfin de nouveaux composés qui constituent des intermédiaires pour les procédés donnant des composés correspondant à ces trois formules.

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