Tricyclic carboxamides

Details Tricyclic carboxamides Tricyclic carboxamides

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 455/03 (2006.01) C07D 455/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2339362

Compounds of formula (I) or salt thereof or solvate thereof, in which: m is 1 or 2; n is 1 or 2; X is CH or N; Y is selected from hydrogen, halogen, cyano, CF3, alkyl or alkoxy; R1, which may be at any position within the saturated ring system, is hydrogen or up to two substituents which may be the same or different and each of which is selected from fluoro and C1-6 alkyl; R2 is hydrogen or up to four substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3- 6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6-alkylCO-, C3- 6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl- C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1- 6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO- , oxazolyl, (C1-4alkyl)NHCO-, CONH2; or R4CONH- or -NR4R5, wherein R4 is hydrogen or C1-4 alkyl; and R5 is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R2 groups are linked together form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O are indicated to be useful in the treatment and pophylaxis of epilepsy, migraine, and other disorders.

La présente invention concerne des composés représentés par la formule (I), ou bien un sel ou un solvate de ces composés, qui conviennent pour le traitement et la prophylaxie de l'épilepsie, de la migraine et autres troubles. Selon cette formule (I), m vaut 1 ou 2; n vaut 1 ou 2; X est CH ou N; Y est pris dans hydrogène, halogène, cyano, CF¿3?, alkyle ou alkoxy; R?1¿, qui peut occuper n'importe quelle position dans le cycle saturé, est hydrogène ou jusqu'à deux substituants, identiques ou différents, pris chacun dans fluoro et alkyle en C¿1-6?; R?2¿ est hydrogène ou jusqu'à quatre substituants pris dans halogène, NO¿2?, CN, N¿3?, CF¿3?O-, CF¿3?S-, CF¿3?CO-, alkyle en C¿1-6?, alcényle en C¿1-6?, alkynyle en C¿1-6?, perfluoroalkye en C¿1-6?, cycloalkyle en C¿3-6?, C¿3-6?cycloalkyle C¿1-4?alkyle-, C¿1-6?alkylO-, C¿1-6? alkylCO-, C¿3-6?cycloalkylO-, C¿3-6?cycloalkylCO-, C¿3-6?cycloalkyle C¿1-4?alkylO-, C¿3-6 ?cycloalkyle C¿1-4?alkylCO-, phényle, phénoxy, benzyloxy, benzoyl, phényl-C¿1-4?alkyl, C¿1-6?alkylS-, C¿1-6? alkylSO¿2?-, (C¿1-4?alkyl)¿2?NSO¿2?-, (C¿1-4?alkyl)NHSO¿2?-, (C¿1-4?alkyl)¿2?NCO-, oxazolyl, (C¿1-4?alkyl)NHCO-, CONH¿2? ; ou R?4¿CONH- ou -R?4¿R?5¿, où R?4¿ est hydrogène ou alkyl en C¿1-4? ; et R?5¿ est hydrogène, alkyle en C¿1-4?, formyl, -CO¿2?C¿1-4?alkyle ou COC¿1-4?alkyle ; ou deux groupes R?2¿ liés et formant un atome carbocyclique ou hétérocyclique, saturé ou insature, substitué ou non par -O¿1?H ou =O.

Affiliated with

Also associated with

Rating

Tricyclic carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic carboxamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2051375