Tricyclic compound

Details Tricyclic compound Tricyclic compound

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/4745 (2006.01) A61P 11/06 (2006.01) A61P 25/00 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2528497

A compound represented by the following formula (1): (1) [wherein R1 represents hydrogen, chlorine, or hydroxy; X1.cndot..cndot..cndot.X2 represents -CH(R2)-CH(R3)-, etc., wherein R2 and R3 each represents hydrogen or alkyl; A1, A11, A2, and A21 each represents hydrogen or alkyl; Y represents -CH(A3)-, -CH(A3)-C(A4)(A41)-, etc. or represents a single bond, wherein A3, A4, and A41 each represents hydrogen or alkyl; and Z represents hydroxy or - N(A6)(A61), wherein A6 represents hydrogen or alkyl and A61 represents hydrogen, alkyl, aralkyl, etc.] or a salt of the compound. The compound or salt potently inhibits the phosphorylation of myosin-control light chains.

L'invention concerne un composé représenté par la formule (1) suivante : (1) [dans laquelle R?1¿ représente hydrogène, chlore ou hydroxy ; X?1¿...X?2¿ représente -CH(R?2¿)- CH(R?3¿)- etc., R?2¿ et R?3¿ représentant chacun hydrogène ou alkyle ; A?1¿, A?11¿, A?2¿ et A?21¿ représentent chacun hydrogène ou alkyle, Y représente -CH(A?3¿)-, -CH(A?3¿)-C(A?4¿)(A?41¿)- etc. ou une liaison simple, A?3¿, A?4¿ et A?41¿ représentant chacun hydrogène ou alkyle ; et Z représente hydroxy ou N(A?6¿)(A?61¿), A?6¿ représentant hydrogène ou alkyle et A?61¿ représentant hydrogène, alkyle, aralkyle etc.] ou un sel de ce composé. Ce composé ou sel est un puissant inhibiteur de la phosphorylation des chaînes légères régulatrices de la myosine.

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