Tricyclic compound having anti-allergic activities

Details Tricyclic compound having anti-allergic activities Tricyclic compound having anti-allergic activities

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2134451

-110- ABSTRACT OF THE DISCLOSURE A nitrogen-containing tricyclic compound represented by formula (I): Image (I), a salt thereof, or a solvate of said compound or said salt, wherein R represents phenyl or naphthyl group which is unsubstituted or substituted at one to five sites with a group such as a halogen atom; a straight chain or branched alkyl group containing 1 to 10 carbon atoms which is unsubstituted or substituted with one or more halogen atoms; or the like; Y represents hydrogen atom; and Z represents a group such as hydrogen atom, hydroxyl group, or the like; or Y and Z together represent a group such as hydrazono group, hydroxyimino group, or the like which is unsubstituted or substituted with a particular group; and x1 - X2 ~ C ~ X3 represents CH-N-C=C or N-C=C-N; provided that when X1 - X2 ~ C ~ X3 represents N-C=C-N, Y and Z does not together represent hydroxyimino group or oxygen atom; is capable of inhibiting the production of IgE antibody, and therefore, is useful as a prophylactic and/or therapeutic agent for allergic diseases.

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