Tricyclic compounds

Details Tricyclic compounds Tricyclic compounds

C - Chemistry, Metallurgy

07

D

167/207, 260/300

C07D 333/74 (2006.01) A61K 31/38 (2006.01) C07D 495/04 (2006.01) C07D 495/10 (2006.01)

Patent

CA 1284326

Tricyclic compounds Abstract of the Disclosure Pharmaceutical preparations containing compounds of formula I Image wherein ring A is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of lower alkyl, hydroxy, lower alkoxy, lower alkylenedioxy, lower alkanoyloxy, halogen, lower alkylamino, di-lower alkylamino, lower alkanoylamino, lower alkanoyl, carboxy and lower alkoxycarbonyl, R1 and R2, independently of one another, each represents hydrogen, lower alkyl or phenyl which is unsubstituted or substituted in the same manner as indicated above for the ring A, or R1 and R2 together denote lower alkylene, Y is methylene, methylene monosubstituted by lower alkyl, oxygen, sulfur, sulfinyl or sulfonyl, X represents a bivalent radical -S-C[-B-(Z)n]=CH- the sulfur group S of which is bonded directly to the .alpha. - or to the .beta.- position of the bicyclic ring system, B denotes a direct bond, lower alkylene or lower alkenylene, n is 1 or, in case B is lower alkylene or lower alkenylene, may be also 2 or 3, and Z represents carboxy, alkoxycarbonyl, carbamoyl which is unsubstituted or substituted by one or two equal or different radicals selected from the group consisting of lower alkyl, phenyl-lower alkyl wherein in turn the phenyl group is unsubstituted or substituted in the same manner as indicated above for the ring A, amino, lower alylamino and di-lower alkylamino; lower alkanoyloxy-methoxycarbonyl, amino-lower alkanoyloxy- methoxycarbonyl, lower alkanoylamino-methoxycarbonyl, 3- phthalidyloxy-carbonyl, 1-lower alkoxycarbonyloxy-lower alkoxycarbonyl, 1-lower alkoxy-lower alkoxycarbonyl, 2-oxo-1, 3- dioxolen-4-ylmethoxycarbonyl that is unsubstituted or substituted by lower alkyl or phenyl in 5-position of the dioxolene ring, carboxymethyl-carbamoyl; cyano; hydroxycarbamoyl, 5-tetrazolyl, unsubstituted or lower alkyl-substituted 4, 5-dihydro-2-oxazolyl; formyl; iminomethyl which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkanoyloxy; lower alkanoyl which is unsubstituted or substituted by halogen; benzoyl, or phenyl- lower alkanoyl the latter two radicals being unsubstituted or substituted in the phenyl ring as indicated above for the ring A, sulfo, lower alkoxy-sulfonyl, sulfamoyl, lower alkylsulfamoyl, di- lower alkylsulfamoyl, hydroxy, lower alkoxy, alkanoyloxy, amino, lower alkylamino, di-lower alkylamino, lower alkyleneamino, N- morpholino, N-thiomorpholino, N-piperazino which is unsubstituted or substituted by lower alkyl at its nitrogen atom in 4-position, lower alkanoylamino, halo-lower alkanoylamino, nitro or halogen; or a tautomer, a stereoisomer or an optical isomer thereof, or a mixture of optical isomers; or a pharmaceutically acceptable salt thereof, together with a pharamaceutically acceptable carrier or excipient. These preparations are useful as smooth muscle relaxants, mucoregulators and also prevent hepatic necrosis and have immunomodulatory properties.

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