Tricyclic compounds

Details Tricyclic compounds Tricyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/44 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2055680

NEW TRICYCLIC COMPOUNDS ABSTRACT OF THE DISCLOSURE 5-HT receptor antagonist compounds of Formula I Image in which: the dashed line denotes an optional bond; X and Y are independently selected from hydrogen, halogen, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, aminocarbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or -N(R2)-; R1 and R2 are independently selected from hydrogen and lower alkyl or are together -(CH2)n- wherein n is an integer from 2 to 4; and FF27170.HVM 27170-FF R3 is selected from Image (a) Image (b) Image (c) Image (d) in which: p is 0 or 1; q is 1, 2 or 3; and R4 is C1-7 alkyl; their pharmaceutically acceptable salts, individual isomers or mixtures of isomers, processes for their preparation, compositions containing them, and their methods of use. FF27170.HVM 27170-FF

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