C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/47 (2006.01) C07D 451/00 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 453/00 (2006.01) C07D 453/02 (2006.01)
Patent
CA 2042443
ABSTRACT OF THE DISCLOSURE Compounds of Formula I: Image I in which Z is an oxo group or two hydrogens; X and Y are independently selected from hydrogen, halogen, hydroxy, lower alkoxy, benzyloxy, lower alkyl, lower cycloalkyl, nitro, amino, amino-carbonyl, (lower alkyl)amino, di(lower alkyl)amino and (lower alkanoyl)amino; R1 is selected from Image (a) Image (b) Image (c) Image (d) in which p is 0 or 1; n is 1, 2 or 3; and R2 is hydrogen, lower alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl, or a group (CH2)tR3 where t is 1 or 2 and R3 is thienyl, pyrrolyl or furyl optionally further substituted by one or two substituents selected from lower alkyl, lower alkoxy, trifluoromethyl or halogen, or is phenyl optionally substituted by one or two substituents selected from C1-4 alkoxy, trifluoromethyl, halogen, nitro, carboxy, esterified carboxy, and C1-4 alkyl optionally substituted by hydroxy, C1-4 alkoxy, carboxy, esterified carboxy or in vivo hydrolyzable acyloxy; or their pharmaceutically acceptable salts, or an individual isomer or mixture of isomers thereof, the processes for the preparation thereof, as well as compositions containing them and their methods of use.
Berger Jacob
Clark Robin D.
Eglen Richard M.
Smith William L.
Weinhardt Klaus K.
Berger Jacob
Clark Robin D.
Eglen Richard M.
Johnson Douglas S. Q.c.
Smith William L.
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