Tricyclic compounds

Details Tricyclic compounds Tricyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/4245 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) A61P 1/04 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 17/08 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 413/10

Patent

CA 2677661

PPAR.gamma. agonists containing tricyclic compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof as the active ingredient, wherein R1 is optionally substituted lower alkyl or the like; R2 and R3 may be the same or different and are each optionally substituted lower alkyl or the like; R4 and R5 may be the same or different and are each hydrogen or the like; Q1-Q2-Q3 is CH=CH-CH=CH or the like; Y is a single bond or the like; Z1-Z2 is C=CR13 or the like wherein R13 is hydrogen or the like; and A is -COOH or the like.

La présente invention concerne des agonistes de PPAR.gamma. dont le principe actif est l'un des composés tricycliques représentés par la formule générale (I) ou l'un de ses sels pharmaceutiquement admis. Dans cette formule, R1 est alkyle inférieur éventuellement substitué ou analogue. R2 et R3, qui sont identiques ou différents, sont chacun alkyle inférieur éventuellement substitué ou analogue. R4 et R5, qui sont identiques ou différents, sont chacun hydrogène ou analogue. Q1-Q2-Q3 est CH=CH-CH=CH ou analogue. Y est liaison simple ou analogue. Z1-Z2 est C=CR13 ou analogue, R13 étant hydrogène ou analogue. Enfin, A est -COOH ou analogue.

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