Tricyclic compounds and intermediates thereof

Details Tricyclic compounds and intermediates thereof Tricyclic compounds and intermediates thereof

C - Chemistry, Metallurgy

07

D

C07D 313/12 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07C 233/58 (2006.01) C07C 233/65 (2006.01) C07D 223/20 (2006.01) C07D 337/12 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01)

Patent

CA 2059792

Disc1osed is a tricyc1ic compound represented by the formula (I): Image wherein each of R1, R2, R3 and R4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, vitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR9R10C02R11 (wherein each of R9, R10 and R11 independently represents hydrogen or C1-6 alkyl) or CONR12R13 (wherein each of R12 and R13 independently represents hydrogen or C1-6 alkyl) R5 represents hydrogen or C1-6 alkyl; each of R6; R7 and R8 independently represents hydrogen, C1-6 alkyl, hydroxy; C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y1-Y2 represents CH2-O, CH2-S(O)n; (wherein n represents 0, 1, or 2), CH2CH2, CH=CH or CON(R14) (wherein R14 represents hydrogen or C1-6 alkyl) and Z represents oxygen or sulfur, or a pharmaceutically acceptable salt thereof. The compound possesses an acyl coenzyme A: cholesterol acyltransferase-inhibiting activity, and thus are expected to have preventive and therapeutic effects on hyperlipemia and arteriosclerosis.

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