Tricyclic compounds and their use

Details Tricyclic compounds and their use Tricyclic compounds and their use

A - Human Necessities

61

K

167/244, 167/322

A61K 35/18 (2006.01) A61L 2/16 (2006.01)

Patent

CA 1229304

ABSTRACT Tricyclic compounds of formula (I) Image (I) wherein X1 is a carboxyl or 5-tetrazolyl group X2 is carbonyl or methylene X3 is hydroxyl or a group -X4(CnH2n)X5 where X4 is oxygen or sulphur X5 is hydrogen or a group -OX6 where X6 is hydrogen, alkanoyl of 1 to 4 carbon atoms or a group -(CmH2m)X7 where X7 is hydrogen or a group -OX8 where X8 is hydrogen or alkanoyl of 1 to 4 carbon atoms and m and n are each, independently, an integer from 1 to 4, together with salts thereof, provided that when X5 is a group -OX6 then n is always greater than 1 and X4 and X5 are attached to different carbon atoms and that when X7 is a group -OX8 then m is always greater than 1 and no single carbon atom in the radical -(CmH2m)- is attached to two oxygen atoms, provide a more effective delivery of oxygen to the tissues; of tissue hypoxia as in, for example, cardiac or cerebral ischaemia in vitro they maintain the oxygen-delivery capacity of stored red blood cells and prolong the cells' useful storage life.

514519

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