Tricyclic compounds as matrix metalloproteinase inhibitors

Details Tricyclic compounds as matrix metalloproteinase inhibitors Tricyclic compounds as matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 333/76 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2685389

The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.

L'invention concerne des composés de formule I et des sels pharmaceutiquement acceptables et des ester de ceux-ci, R1, R2, R3, R4, X, et Y étant définis. Les présentes informations concernent également des procédés de préparation de composés de formule I et des procédés d'inhibition de métalloprotéinases matricielles, en particulier, MMP-12, qui peuvent être impliquées dans des troubles pathologiques rencontrés chez des mammifères, y compris chez l'homme.

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