Tricyclic compounds as matrix metalloproteinase inhibitors

Details Tricyclic compounds as matrix metalloproteinase inhibitors Tricyclic compounds as matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/4155 (2006.01) A61K 31/4192 (2006.01) A61K 31/443 (2006.01) A61K 31/5377 (2006.01) C07D 333/76 (2006.01) C07D 405/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2667644

The present invention relates to compositions of the formula (I): and pharmaceutically acceptable salts, hydrates, or esters thereof, wherein R1, R2, R3, R4, R5, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating pathologic conditions or disorders mediated wholly or in part by matrix metalloproteinases, such as asthma and chronic obstructive pulmonary disease, comprising administering a therapeutically effective amount of a compound of formula (I) to a mammal (e.g., a human) in need thereof.

La présente invention concerne des composés de formule (I) : et des sels, hydrates ou esters acceptables du point de vue pharmaceutique de ceux-ci, R1, R2, R3, R4, R5, X et Y étant tels que définis ici. La présente invention concerne également des procédés de fabrication des composés de formule (I) et des procédés de traitement d'affections ou troubles pathologiques induits entièrement ou en partie par des métalloprotéases matricielles, tels que l'asthme et une bronchopneumopathie chronique obstructive, lesquels consistent à administrer une quantité efficace du point de vue thérapeutique d'un composé de formule (I) à un mammifère (par exemple à un humain) qui en a besoin.

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