Tricyclic compounds as modulators of tnf-.alpha. synthesis...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) C07D 239/95 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01)

Patent

CA 2711576

The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF- alpha or by PDE4, including but not limited to rheumatoid arthritis.

La présente invention concerne des composés chimiques de formule (I) qui sont tels que définis ici, des compositions pharmaceutiques et des procédés d'utilisation dans le traitement d'affections ou de troubles médiés par TNF-alpha ou par PDE4, notamment, de manière non limitative, la polyarthrite rhumatoïde.

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