Tricyclic compounds bearing acyloxymethoxycarbonyl pendants

Details Tricyclic compounds bearing acyloxymethoxycarbonyl pendants Tricyclic compounds bearing acyloxymethoxycarbonyl pendants

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 31/136 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/505 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07D 213/70 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/77 (2006.01) C07D 239/26 (2006.01) C07D 239/34 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2375909

Compounds of general formula (I), salts of the same, and solvates of both; and drug compositions containing them: wherein X and X' are each -N(COOCR3R2OCOR1)- , -O-, or the like (wherein R1 is lower alkyl substituted with carbamoyl, lower alkylcarbamoyl, carbamoyloxy, lower alkylcarbamoyloxy, acetylamino, or the like; and R2 and R3 are each hydrogen or the like); Y and Y' are each lower alkyl, lower alkenyl, or the like; A, B and C are each an optionally substituted aromatic carbocycle, an optionally substituted heterocycle, or the like; W1, W2, and W3 are each a bond or the like; and V1 and V2 are each a single bond or the like.

L'invention concerne des composés de la formule générale (I), des sels de ceux-ci, et leurs solvates, ainsi que des compositions de médicaments les contenant, formule dans laquelle X et X' représentent chacun -N(COOCR?3¿R?2¿OCOR?1¿)-, -O- ou analogue (où R?1¿ représente alkyle inférieur substitué par carbamoyle, alkyle carbamoyle inférieur, carbamoyloxy, alkylcarbamoyloxy inférieur, acétylamino ou analogue; et R?2¿ ainsi que R?3¿ représentent chacun hydrogène ou analogue; Y et Y' représentent chacun alkyle inférieur, alcényle inférieur ou analogue; A, B et C représentent chacun un carbocycle aromatique facultativement substitué, un hétérocycle facultativement substitué ou analogue; W?1¿, W?2¿ et W?3¿ représentent chacun une liaison ou analogue; et V?1¿ ainsi que V?2¿ représentent chacun une liaison simple ou analogue.

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