C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2730319
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxal sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
La présente invention porte sur des composés tricycliques, sur des sels, promédicaments, solvates ou hydrates pharmaceutiquement acceptables de ceux-ci, ayant une activité antimitotique, une activité de résistance contre plusieurs médicaments, par exemple une inhibition de la glycoprotéine P, et une activité antitumorale, et qui inhibent des cellules tumorales sensibles et résistantes au paclitaxel. L'invention porte également sur des procédés d'utilisation de ces composés pour le traitement des cellules tumorales et l'inhibition de la mitose de cellules cancéreuses.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Duquesne University Of The Holy Spirit
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