C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2712347
There is provided a compound of the formula (I) wherein X is a nitrogen or CRx, Rx is a hydrog? n, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted hydrocarbon group, etc., ring A is 5- to -8-membered heterocyclic ring, etc., and each of Y1,. Y2 and Y3 is an optionally substituted carbon or a nitrogen, etc.; or 'a salt thereof or a pro- drug thereof., which have CRF receptor antagonistic activity and use thereof.
L'invention concerne un composé représenté par la formule (I') dans laquelle X est de l'azote ou CRx, Rx est de l'hydrogène, etc., R1 est un groupe hydrocarbure éventuellement substitué, etc., R2 est un groupe hydrocarbure éventuellement substitué, etc., le noyau A est un noyau hétérocyclique de 5 à 8 chaînons, etc., et Y1, Y2 et Y3 sont chacun du carbone ou de l'azote éventuellement substitués, etc.. L'invention concerne également un sel ou un promédicament dudit composé, présentant une activité antagoniste sur le récepteur CRF, ainsi que leur utilisation.
Aso Kazuyoshi
Hoashi Yasutaka
Kobayashi Katsumi
Kojima Takuto
Mochizuki Michiyo
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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