Tricyclic compounds protein kinase inhibitors for enhancing...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/06 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2512683

Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R2, R3 and R4 are as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti- neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions, such as cancers.

L'invention concerne une protéine kinase, telle que CHK-1, inhibant des composés tricycliques de formule (I) (dans laquelle R?2¿, R?3¿ et R?4¿ sont tels que définis dans la spécification), des compositions pharmaceutiques contenant des quantités efficaces desdits composés ou leurs sels, utiles en tant qu'agent seul ou combiné à un agent anti-néoplasique ou à un rayonnement thérapeutique, possédant un effet anti-néoplasique pour le traitement de maladies ou d'états, tels que le cancer.

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