Tricyclic compounds useful as angiotensin ii agonists

Details Tricyclic compounds useful as angiotensin ii agonists Tricyclic compounds useful as angiotensin ii agonists

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4174 (2006.01) A61P 43/00 (2006.01) C07D 409/10 (2006.01) C07D 521/00 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2449150

There is provided compounds of formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

L'invention concerne des composés de formule (I), dans laquelle X¿1?, X¿2?, X¿3?, X¿4?, Y¿1?, Y¿2?, Y¿3?, Y¿4?, Z¿1?, Z¿2?, R?4¿ et R?5¿ ont les significations indiquées dans la description, ainsi que des sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont utiles comme agonistes sélectifs du récepteur AT2 et donc, en particulier, pour traiter notamment des affections gastro-intestinales, telles que la dyspepsie, le syndrome du côlon irritable et le syndrome de défaillance polyviscérale, ainsi que des troubles cardiovasculaires.

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