C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 491/107 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2630562
The present invention provides inhibitors of kinases, specifically I.kappa.B kinases, JAKl , JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-.kappa.B-mediated diseases.
La présente invention concerne des inhibiteurs de kinases, de manière spécifique de kinases I?B JAK1, JAK2, JAK3 et TYK2. Cette invention concerne également des compositions comprenant de tels composés inhibiteurs, ainsi que des procédés pour inhiber l'activité de kinase qui consistent à administrer ledit composé à un patient nécessitant un traitement pour lutter contre le syndrome myéloprolifératif, le cancer ou des maladies à médiation par NF-?B.
Isabel Elise
Lachance Nicolas
Lau Cheuk K.
Leblanc Yves
Mellon Christophe
Merck & Co. Inc.
Merck Frosst Canada Ltd.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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