Tricyclic derivatives, compositions and methods of use

Details Tricyclic derivatives, compositions and methods of use Tricyclic derivatives, compositions and methods of use

C - Chemistry, Metallurgy

07

C

C07C 211/32 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) C07C 215/38 (2006.01) C07C 217/48 (2006.01) C07C 233/05 (2006.01) C07C 311/17 (2006.01) C07D 313/14 (2006.01) C07D 491/044 (2006.01)

Patent

CA 2175313

-49- Disclosed are compounds of Formula I: Image (I) or a pharrnaceutically acceptable salt or solvate thereof, wherein: R4 is alkenyl, alkoxy, or -OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha., and methods for treating septic shock, inflammation, or allergic disease.

On divulgue des composés de formule I : Image (I) ou un sel ou soluté pharmaceutiquement acceptable de ces derniers, où : R4 est un groupe alkényle, alcoxy ou -OH. On divulgue également des compositions pharmaceutiques contenant des composés de formule I, des méthodes pour inhiber le facteur nécrosant des tumeurs-alpha et des méthodes pour traiter le choc septique, l'inflammation ou les affections allergiques.

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