Tricyclic derivatives, compositions and methods of use

Details Tricyclic derivatives, compositions and methods of use Tricyclic derivatives, compositions and methods of use

C - Chemistry, Metallurgy

07

C

C07C 211/32 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 217/48 (2006.01) C07C 217/52 (2006.01) C07C 229/14 (2006.01) C07C 233/05 (2006.01) C07C 233/18 (2006.01) C07C 251/40 (2006.01) C07C 271/16 (2006.01) C07D 295/03 (2006.01) C07D 313/14 (2006.01)

Patent

CA 2175287

Disclosed are compounds of Formula I: Image (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: R3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl; R4 is H, alkyl, alkenyl, alkoxy, or -OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.

On divulgue des composés de formule I : Image (I) ou un sel ou soluté pharmaceutiquement acceptable de ces derniers, où : R3 est un groupe alkyle, alkényle, alkynyle, aryle, alkaryle, aralkyle, cycloalkyle, acyloxyméthyle, alcoxy, alcoxyméthyle ou alkyle substitué par un cycloalkyle; R4 correspond à H, à un groupe alkyle, alkényle, alcoxy ou -OH. On divulgue également des compositions pharmaceutiques contenant les composés de formule I, des méthodes pour inhiber le facteur nécrosant des tumeurs-alpha et des méthodes pour traiter le choc septique, l'inflammation ou les affections allergiques par l'administration d'un composé de formule I.

Affiliated with

Also associated with

Rating

Tricyclic derivatives, compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic derivatives, compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic derivatives, compositions and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1745049