Tricyclic heterocyclic derivatives

Details Tricyclic heterocyclic derivatives Tricyclic heterocyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 219/06 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 31/20 (2006.01) C07C 209/88 (2006.01) C07C 211/09 (2006.01) C07C 249/14 (2006.01) C07D 219/08 (2006.01) C07D 401/10 (2006.01) C07D 413/10 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2048298

ABSTRACT TITLE: TRICYCLIC HETEROCYCLIC DERIVATIVES The invention relates to tricyclic heterocyclic derivatives, or pharmaceutically-acceptable salts or in vivo hydrolysable esters thereof, which possess anti-cancer activity. The invention also relates to processes for the manufacture of said tricyclic heterocyclic derivatives, to novel pharmaceutical compositions containing them and to the use of said tricyclic heterocyclic derivatives in the manufacture of a medicament for the production of an anti-cancer effect. The invention provides an optionally substituted tricyclic heterocyclic derivative of the formula I Image wherein A together with the adjacent vinylene group of the 4-oxo-1,4- dihydropyrid-1-yl ring completes a benzene or pyridine ring; R1 and R2, which may be the same or different, each is (1-4C)alkyl or (1-4C)alkoxy; and R3 is hydrogen, (1-4C)alkyl or (1-4C)alkoxy; or a pharmaceutically-acceptable salt or in vivo hydrolysable ester thereof.

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