C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/55 (2006.01) C07D 471/22 (2006.01) C07D 491/048 (2006.01)
Patent
CA 2238524
The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the phenyl ring with halo, N(R)2, wherein each R is H or (C1-C4)alkyl; or NO2; and R4 is (C3- C6)cycloalkyl(C1-C4)alkyl, (C3-C6)cycloalkyl or (C1-C4)alkyl, optionally containing 1-2 double bonds, and the pharmaceutically acceptable salts thereof, useful to treat cocaine addiction and the use of other addictive substances.
Série d'analogues d'ibogaïne de formule (I) dans laquelle R¿1? est S ou O; R¿2? est H, alkyle (C¿1?-C¿4?), alcoxy (C¿1?-C¿4?), OH, CN, CONH¿2?, halo, oxazolyle, alkyls (C¿1?-C¿4?) ou trifluoroalkyle (C¿1?-C¿2?); R¿3? est un groupe phényle éventuellement substitué en position 2' ou 3' du cycle phényle avec halo, N(R)¿2?, chaque R étant H ou alkyle (C¿1?-C¿4?); ou NO¿2?; et R¿4? est cycloalkyle (C¿3?-C¿6?)-alkyle (C¿1?-C¿4?), cycloalkyle (C¿3?-C¿6?) ou alkyle (C¿1?-C¿4?), contenant éventuellement 1 ou 2 liaisons doubles, ainsi que sels pharmaceutiquement acceptables desdits analogues, utiles pour traiter la dépendance à la cocaïne et l'utilisation d'autres substances créant l'accoutumance.
Efange S. Mbua Ngale
Mash Deborah Carmen
Gowling Lafleur Henderson Llp
The Regents Of The University Of Minnesota
University Of Miami
LandOfFree
Tricyclic ibogaine analogs, their preparation and their use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic ibogaine analogs, their preparation and their use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic ibogaine analogs, their preparation and their use... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1686451