Tricyclic indole-2-carboxylic acid derivatives

Details Tricyclic indole-2-carboxylic acid derivatives Tricyclic indole-2-carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/90 (2006.01) A61K 31/395 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2135811

-1- Abstract The present invention is directed to a tricyclic indole-2-carboxylic acid derivative represented by the formula 1: Image 1 wherein X represents alkyl, halogen or cyano; R1 represents hydrogen, or a protecting group of carboxyl group; W represents hydrogen, -CO2R3i, -CONR3iR4i, -A-CO2R3i or -A-CONR3iR4i, wherein -A- represents alkylene and R3i and R4i independently represent hydrogen, alkyl, aryl or substituted aryl, or a pharmaceutically acceptable salt thereof. These compounds of the present invention are selective antagonists of glycine binding site of the N- methyl-D-aspartate (NMDA) receptor.

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