C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/14 (2006.01) A61K 31/55 (2006.01) A61K 31/554 (2006.01) C07D 513/06 (2006.01)
Patent
CA 2523291
The present invention relates to novel hydroxyethylamine compounds having Asp2 (.beta.-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated .beta.- amyloid levels or .beta.-amyloid deposits, particularly Alzheimer's disease.
La présente invention concerne de nouveaux composés d'hydroxyéthylamine ayant une activité d'inhibition de Asp2 (.szlig.-secrétase, BACE1 ou mémapsine), des procédés pour les préparer, des compositions les contenant et leur utilisation dans le cadre du traitement de maladies se caractérisant par des taux élevés en .szlig.-amyloïde ou des dépôts de .szlig.-amyloïde, en particulier la maladie d'Alzheimer.
Demont Emmanuel Hubert
Redshaw Sally
Walter Daryl Simon
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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