Tricyclic inhibitors of 5-lipoxygenase

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61K 31/4985 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2636043

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or Ieukotriene mediated conditions, diseases, or disorders.

L~invention concerne des composés et des compositions pharmaceutiques comprenant de tels composés, qui inhibent l~activité de la 5-lipoxygénase (5-LO). L~invention concerne également des procédés d~utilisation de tels inhibiteurs de la 5-LO, seuls ou en association avec d~autres composés, en vue de traiter des troubles, des pathologies ou des états respiratoires, cardiovasculaires et autres induits ou dépendant des leucotriènes.

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