Tricyclic inhibitors of farnesyl protein transferase

Details Tricyclic inhibitors of farnesyl protein transferase Tricyclic inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2266016

Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

L'invention porte sur de nouveaux composés de formule (1.0) représentés par les formules (1.4) ou (1.5) dans lesquelles R<1>, R<3> et R<4> sont chacun sélectionnés indépendamment parmi halo. L'invention porte également sur des procédés d'inhibition de la farnésyl-protéine transférase et de la croissance des cellules anormales, par exemple cancéreuses.

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