Tricyclic inhibitors of fatty acid amide hydrolase

Details Tricyclic inhibitors of fatty acid amide hydrolase Tricyclic inhibitors of fatty acid amide hydrolase

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2689148

A series of substituted oxazole compounds having an alpha keto side chain at the 2 position and an aromatic, heteroaromatic or heterocycle substituent at the 5 position are disclosed. These compounds exhibit inhibition of fatty acid amid hydrolase and are useful for treatment of malconditions involving that enzyme.

La présente invention concerne une série de composés d'oxazole substitués comprenant une chaîne latérale alpha céto en position 2 et un substituant aromatique, hétéroaromatique ou hétérocyclique en position 5. Ces composés présentent une inhibition de l'enzyme FAAH et sont utiles pour le traitement de troubles impliquant cette enzyme.

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