C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/10 (2006.01) A61K 31/41 (2006.01) A61P 3/10 (2006.01) C07D 261/06 (2006.01) C07D 263/30 (2006.01) C07D 277/20 (2006.01)
Patent
CA 2691309
The present invention provides tricyclic compounds according to formula (I): (I) where R1, R2, R3, W, X, Y, Z, m, n, and p are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11 -HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
La présente invention concerne des composés tricycliques selon la formule (I) : (I) dans laquelle R1, R2, R3, W, X, Y, Z, m, n, et p sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques les comprenant, des procédés d'utilisation des composés et des compositions de l'invention pour le traitement de conditions associées aux hydroxystéroïde déshydrogénases (par exemple, la 11-HSD1), et l'utilisation des composés de l'invention dans la préparation de médicaments pour le traitement de conditions associées aux hydroxystéroïde déshydrogénases.
Gonzalez Lopez de Turiso Felix
Julian Lisa
Powers Jay P.
Sun Daqing
Yan Xuelei
Amgen Inc.
Smart & Biggar
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