Tricyclic inhibitors of matrix metalloproteinases

Details Tricyclic inhibitors of matrix metalloproteinases Tricyclic inhibitors of matrix metalloproteinases

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 251/48 (2006.01) C07C 251/86 (2006.01) C07D 209/82 (2006.01) C07D 221/06 (2006.01) C07D 311/80 (2006.01) C07D 333/76 (2006.01) C07D 335/10 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2220040

Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Cette invention concerne des composés tricycliques, ainsi que des procédés de préparation et des compositions pharmaceutiques de ces composés, lesquels sont utiles en qualité d'inhibiteurs de métalloprotéinases matricielles, notamment de gélatinase A (gélatinase 72 kD ) et de stromelysine-1, ainsi que dans le traitement de la sclérose en plaques, de la rupture de plaques athéroscléreuses, de l'anévrisme de l'aorte, d'insuffisances cardiaques, de la resténose, de maladies périodontiques, de l'ulcération cornéenne, de métastases de cancer, de l'angiogénèse tumorale, de l'arthrite ou d'autres troubles auto-immuns ou inflammatoires dus à l'invasion de tissus par des leucocytes.

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