Tricyclic inhibitors of poly(adp-ribose) polymerases

Details Tricyclic inhibitors of poly(adp-ribose) polymerases Tricyclic inhibitors of poly(adp-ribose) polymerases

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/4375 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 243/00 (2006.01) C07D 487/00 (2006.01) C07D 487/06 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2360003

Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

Cette invention concerne des composés représentés par la formule (I) ci-dessous qui sont des inhibiteurs de la poly(ADP-ribosyl)transferase (PARP) et qui sont utiles pour le traitement des cancers et atténuent les effets d'attaques, de traumatismes crâniens et des maladies neurodégénératives. En tant qu'agents thérapeutiques des cancers, les composés selon l'invention peuvent s'employer notamment en combinaison avec des agents cytotoxiques et/ou des rayons.

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